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and that case-fatality rates increase with age and with chronic disease comorbidity, both of which are associated with lower 25(OH)D concentration (33)

Maternal hypothyroidism caused by iodine deficiency is associated with adverse pregnancy outcomes and impaired fetal growth, such as spontaneous abortion, premature birth, fetal death, low birth weight, neonatal mortality, growth restriction, altered cognitive development (cretinism, language disorders, altered motor development) [119]

Each step must be performed carefully to maintain compound integrity