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Consequently, an exhaustive examination of mitochondrial function and energy regulation mechanisms will establish the theoretical foundation for targeting mitochondria in cancer treatment

Relevant synthetic alkylating agents that are dealt with in this review can be subdivided into the following compound classes: mustards (e.g., nitrogen mustards such as mechlorethamine, melphalan, chlorambucil, bendamustine, cyclophosphamide, estramustine), diazomethane forming prodrugs (e.g., dacarbazine, temozolomide), and N -nitrosoureas (e.g., BCNU/carmustine)

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