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Other transcription factors such as myelin gene regulatory factor ( Myrf ) are essential for CNS myelination such that when the membrane-bound Myrf protein undergoes an activating cleavage event, its cleavage product can localize into the nucleus to bind and enhance the expression of pro-myelin genes such as Plp1, Mbp, Mag, and Trf (Bujalka et al., via activation of the Fyn kinase pathway as well as promote OPC migration and survival via focal adhesion kinase (FAK) mediated signaling (Relucio et al., 2009, 2012

This framework helps distinguish between generic supplementation and personalized metabolic support