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All experimental methods were approved by the KCHRC, Goraj Institutional Ethics Committee prior to implementation

Secondly, excess intracellular Fe 2+ can generate highly reactive hydroxyl (HO) radicals through the Fenton reaction, leading to the continuous accumulation of intracellular ROS and resulting in ferroptosis [31, 32]

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They have an inability to hand off to the adaptive immune system to call in the troops to put out the fires of inflammation, so they stay stuck in a chronic innate inflammatory response