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261 Several PMO-based NADs have been approved for treating DMD, including eteplirsen (Exondys 51), 262 golodirsen (Vyondys 53 ), 80 viltolarsen (Viltepso ), 263 and casimersen (Amondys )

This sustained WBC elevation can reflect the activity or severity of the underlying disease and sometimes guides treatment decisions

The newly formed cysteinylglycine S -conjugates are further processed by dipeptidases/aminopeptidases to remove the glycyl group and produce cysteine S -conjugates

Secondly, aging contributes to heightened hyperexcitability in cortical networks, consequently escalating the energy requirements for axonal propagation of action potentials and synaptic neurotransmitter release [80,81]