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Brattas PL, Hersbach BA, Madsen S, Petri R, Jakobsson J, Pircs K

The above-mentioned findings point to silibinin as a clinically promising substance that can be further developed as a therapeutic candidate for the prevention and treatment of chronic diseases in humans

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The biosynthesis of these compounds requires several cytochrome P450-dependent hydroxylation steps, and the involvement of numerous members of the cytochrome P450 family (encoded by the CYP genes)