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342 However, the damaged mitophagy leads to ROS accumulation, inflammasome activation, and lipid accumulation, which results in cell damage

An enzyme typically, but not exclusively, found in the endoplasmic reticulum of eukaryotes that catalyses the formation and breakage of disulfide bonds between cysteine residues

In 1956, a dermatologist named Alan Lyell described a mucocutaneous condition similar to but more severe than SJS, toxic epidermal necrolysis (TEN) or Lyells syndrome

A diagnosis of severe AUD conferred an age-dependent increased risk for ALD, with highest impact in those 70: HR 4.01, 95%CI 2.71-5.93, p 70 years: HR 0.12, CI 0.02-0.97, p=0.046), but not in patients 10d