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[64], treatment with acetyl-l-carnitine (500 mg twice daily intramuscularly for 10 days followed by 2000 mg daily administered orally for 355 days) resulted in improvement in neurophysiological parameters and pain reduction over a 1-year period [64]

On the other hand, R254X in Saudi Arabia patients had a different haplotype (our unpublished data) and it arose independently (marked as triangle in Figure 2)

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Individual metabolic differences A variety of individual physiological factors, including the severity of obesity, basal metabolic rate and insulin sensitivity, can significantly interfere with and alter the actual fat-reducing efficacy of topical L-carnitine