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Moreover, the route of administration (e.g., intraperitoneal, intravenous, oral, or local injection) can substantially alter agent bioavailability, distribution, and pharmacodynamics, which in turn impacts tissue targeting and effectiveness

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Materials and Methods Animals The experimental treatments were carried out according to the guidelines for animal experiments of the Faculty of Disease Animal Model Research Center, Korea Research Institute of Bioscience and Biotechnology (Daejeon, Korea), as well as the Guidelines for the welfare and use of animals in cancer research

BLA: Biologic License Application A BLA contains detailed information on the manufacturing processes, chemistry, pharmacology, clinical pharmacology, and the medical effects of the biological product