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Of enzymes that converts epoxyeicosatrienoic acids (EETs) to DHETs, the levels of microsomal epoxide hydrolase (EPHX1) positively correlated with fibrosis stage, but not soluble epoxide hydrolase (EPHX2)

At the mechanistic level, environmental pollutants first increase intestinal permeability, allowing bacteria and their products to cross the intestinal barrier and activate the immune system, triggering chronic inflammation [230, 231]

FDA Label Prochlorperazine is an antipsychotic agent that works to promote postsynaptic inhibition of dopaminergic neurons

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