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Co-incubation with MK-7, and to a similar extent vitamin K1 (Figure S4A S4B), blunted these phenotypic shifts: Mesenchymal protein induction fell (Figure S3B S3E) while endothelial marker proteins were restored (Figure S3F S3J)

10.1155/1994/493810 95 GovN

The above results suggest that AGEs may regulate the formation of VSMC osteogenesis through HIF-1/PDK4, which may depend on autophagy and oxidative stress