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In this model, inflammation drives a massive upregulation of proangiogenic factors, which overwhelms the antiangiogenic mechanisms of the cornea and results in a secondary ingrowth of both blood and lymphatic vessels from the limbal area into the corneal center 15

Data synthesis The studies varied in terms intervention type, dosage regimens, duration of treatment, study design, and participant characteristics such as disease stage and concurrent medication hence given the substantial heterogeneity, a quantitative meta-analysis was not performed

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doi: 10.1111/jpi.12559 31 LombardoFGiorginiEGioacchiniGMaradonnaFFerrarisPCarnevaliO