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They are formed in the body from normal metabolism (such as converting food to energy) but are increased by exposure to environmental toxins, such as cigarette smoke and air pollution

To measure the forward reaction rates, we mixed RT (10 M) with equal volumes of different concentrations of GSH solutions (5, 10 and 20 mM) at pH 7.4 and monitored the formation of RT-GSH using a fluorimeter ( ex =405 nm

E.TognoliniM.BorgesG.CrozierA

6.1 PD-specific features of oxidative stress 6.1.1 Dopamine oxidation and quinone stress Contemporary syntheses reinforce that dopamine auto-oxidation generates reactive o-quinones and H 2 O 2 that selectively injure substantia nigra neurons through protein modification, mitochondrial compromise, and redox cycling