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The genomics and genetics of oxygen homeostasis

Transport is mediated by a rocking-bundle mechanism involving two principal structural domains: a mobile bundle domain (transmembrane helices 1, 2, 6, and 7) that undergoes conformational changes to permit substrate and ion entry and release and a relatively stationary scaffold domain (transmembrane helices 35 and 810) that provides structural support and guides bundle movements (Forrest and Rudnick 2009