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Nature 509:105109

[PubMed] [Google Scholar] Sadhukhan P, Saha S, Dutta S, Sil PC (2018) mangiferin ameliorates cisplatin induced acute kidney injury by upregulating Nrf-2 via the activation of PI3K and exhibits synergistic anticancer activity with cisplatin

(A) HK-2 cell proliferation was assessed by MTS assay after 6, 12, and 24 h of cisplatin treatment

The CB2 receptor (CB2R) agonist AM1241, an anti-neuroinflammatory compound, modulates the NLRP3 inflammasome and AMP-activated protein kinase (AMPK) signaling pathways to suppress microglial overactivation, thereby reducing seizure frequency and alleviating depressive-like symptoms (Cai et al., 2024)