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In brief, two blinded investigators evaluated the sum of histological evidence of leukocyte influx in both alveolar and interstitial spaces, proteinaceous debris, formation of hyaline membranes and alveolar septal thickening, then weighted the variables according to their relevance in reflecting the lung damage

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Endogenous toxins: the natural by-products of your own metabolism, including used hormones the liver has to clear

The reliability of RNA-seq data was confirmed by qRT-PCR validation of eight representative genes spanning antioxidant defense, calcium signaling, and ion homeostasis