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Although none of the compounds impacted IL-6 production ( Figures 3D, E ) by these cells, colchicine treatment reduced levels of TNF- whereas MCC950 boosted the release of this cytokine ( Figures 3D, E )

CL h , hepatic clearance

Surprisingly, during all the preliminary tests, glutathione drastically decreased cell index

The cells were then washed twice, resuspended with 0.5 ml the assay buffer, and filtered using Cell Strainer (#352235, BD Falcon) spun down at 300 g for 3 min, prior to analysis with a BD FACS Verse Flow Cytometer