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In the published literature, acetaminophen has been reported to be clastogenic when administered a dose of 1,500 mg/kg/day to the rat model (3.6 times the MHDD, based on a body surface area comparison)

This dysregulation exerts dual biological effects: ACSL4 enhances fatty acid accumulation by modulating lipid metabolism regulators (e.g., c-Myc and sterol regulatory element-binding proteins, SREBPs) to drive MM proliferation (Zhang et al., 2023)

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