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Nonetheless, disparities in classification, labeling requirements, and enforcement practices among nations frequently lead to market misunderstandings and a range of product quality (70)

10.1146/annurev-pharmtox-010716-104908 151 Soto-HerederoG.Gmez de Las HerasM

But this usually only happens after someone complains, one practitioner at a time

5 The absolute risk increase is small (around 3 extra cases for every 1,000 people taking the medication for a year), and the effect is partly explained by weight loss rather than the medication itself