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Since high levels of GSTs are expressed in the hepatocytes and it has previously been demonstrated that GSTs display sulfonamidase activity, three sulfonamide prodrugs of metformin were designed and synthesized 120

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doi: 10.1038/nm.4106 236 ReyndersTDevolderLValles-ColomerMVan RemoortelAJoossensMDe KeyserJet al