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Among lymphocytes, CD8 + T cells are particularly sensitive to cholesterol depletion, as low cholesterol levels hinder their proliferation and induce autophagy-mediated apoptosis

3.3 DNA methyltransferase inhibitors in preclinical research 3.3.1 Nucleoside DNMTi Although three nucleoside DNMTis azacitidine, decitabine, and clofarabine are already on the market, they are chemically and metabolically unstable with low bioavailability