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[PMC free article: PMC3144781] [PubMed: 21730304] 185

GSH is composed of glutamate, cysteine, and glycine and is synthesized intracellularly via two reactions catalyzed by -glutamylcysteine ligase (GCL) and GSH synthetase (GS) [5,6]

When the vasculature that feeds it is compromised by inflammation and endothelial damage which chronically elevated homocysteine promotes cognitive performance suffers

One such adaptation she and her colleagues have been studying is an increase in the amount of the enzyme glutamine synthetase, which makes glutamine from other starting materials, namely glucose