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41, e109353 (2022), Abstract Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice: Ritzel, R

Most studies lasted days to weeks

Interestingly, a positive feedback loop could also be established between p38 MAPK and oxidant species, since this kinase can promote the increase in ROS levels (Borodkina et al., 2014), and oxidant species have been shown to activate p38 MAPK in senescent cells (Marmisolle et al., 2017)

The development of related epigenetic drugs is ongoing, offering new therapeutic options for treating these conditions (Table 4)