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Endothelial dysfunction and preeclampsia: role of oxidative stress

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Antimetabolic drugs such as methotrexate or fluorodeoxyuridine and hydroxyurea stimulate DHFR promoter (Eastman et al., 1991)

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As stated above, hyperinsulinemia also compromises GSH synthesis, which is essential to face RONS generated by oxidative catabolic pathways [46]

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Researchers have used this combination to explore how parallel modulation of amylin and GLP-1 receptors may influence metabolic outcomes

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