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A review of curcumin and its derivatives as anticancer agents

taking it after meals may reduce stomach discomfort

127 Causality is difficult to prove, because herbal and dietary supplements are often dispensed without medical supervision, FDA oversight of product quality is minimal, multiple active ingredients contribute to product variability, and product contamination with hepatotoxic substances (toxic herbs or heavy metals) may occur.127, 128, 129 Drug interactions between herbal and dietary supplements and prescription medications may also occur, because medicinal plants can have effects on hepatic P450 enzyme systems