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M2 macrophage polarization reduces the apoptosis of interstitial cells of Cajal in diabetic rats, which is mediated by the activation of Nrf2/HO-1 pathway [37]

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Additionally, a 2025 retrospective study on chronic knee pain showed that 14 out of 16 patients reported significant relief lasting 612 months, and a 2024 pilot study on interstitial cystitis achieved symptom resolution in 10 out of 12 subjects