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Plasma samples from 136 participants with MDD enrolled into the Mayo Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) were profiled at baseline and after 8 weeks of treatment

In the main synthesis pathway, the key enzymes that limit the synthesis rate of taurine are cysteine dioxygenase (CDO) and cysteine sulfinic acid decarboxylase (CSAD), and their enzyme activities directly affect the efficiency of taurine synthesis in the body

[1] It is a ubiquitous compound with a biologically active sulfhydryl group contributed by the cysteine moiety that acts as the active part of the molecule