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doi: 10.1093/jn/129.1.174 91

This is a substantial shift in cellular behavior that directly affects body composition

In type 2 diabetes models, elevated levels of hepatic succinyl-CoA act as a direct donor of succinyl groups, which strongly promotes the succinylation of lysine residues in proteins

These were all 5-HT1b agonists characterized for their ability to inhibit food consumption, but also had effects on other serotonin receptors that lead to unacceptable side effects (cardiac valvular thickening) and were voluntarily withdrawn from the market