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Obesity and diabetes are increasingly recognized as risk factors for PDAC, not only because of the remodelling of the tumour microenvironment but also because of their effects on systemic metabolism [249, 250]

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Importantly, the authors also showed that Slc39a8 localizes to the apical membrane of cholangiocytes and recovers Mn from bile, thereby reducing Mn excretion and maintaining systemic Mn storage 16

Glutathione is more quickly and effectively absorbed into the bloodstream when given via IV, which avoids the GI tract