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The clinical course of MTC is highly variable and unpredictable, ranging from indolent to highly aggressive, depending on multiple factors

Once disseminated, the dormant state persisted even in the absence of hypoxia, which helped isolated tumour cells to resist treatment 150

(I) HEK293 cells were transfected with the expression plasmid of Flag-tagged TLR4, lysed and treated with GST-HBeAg, and then incubated with glutathione beads for the pull-down experiment