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Subcutaneous administration achieves 7085% bioavailability compared to 4050% for oral routes due to hepatic first-pass metabolism

Conceptual confluence: the kynurenine pathway as a common target for ketamine and the convergence of the inflammation and glutamate hypotheses of depression

Benefits: Increased libido and sexual desire Enhanced erectile function Spontaneous erections Darkens skin (tanning effect, may be desired or undesired) Dosing: 0.5-1mg subcutaneous, 2-3x weekly Lower doses minimize tanning if unwanted Side effects: Nausea (common initially) Darkening of skin and moles Increased freckling Facial flushing Best for: Men wanting both sexual enhancement and tanning