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[41] [42] Functional vitamin B 12 deficiency can also develop with heavy regular use of nitrous oxide N 2 O, also known as "laughing gas", by oxidizing the cobalt atom and inactivating the vitamin

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It has anti-aging effects in vitro and in animal models, and has been sold in Russian-speaking countries as well as more broadly over the internet as a supposed treatment for conditions such as arthritis, though only limited studies in humans have been published

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