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doi: 10.1016/j.tins.2013.07.001 98 KarabatsiakisABockCSalinas-ManriqueJKolassaSCalziaEDietrichDEet al

NO reacts with superoxide, forming a stronger oxidant, the peroxynitrite anion (ONOO )

Reductions in oestradiol, the most potent form of oestrogen have been associated with difficulties with both falling and staying asleepDuring the menopausal transition, declining or low progesterone levels, resulting from the failure of a growing follicle to reach sufficient maturation for ovulation, are associated with sleep disturbances