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BDNF binds to the high affinity receptor tropomyosin-related kinase B (TrkB), which activates intracellular signaling cascades critical for neuronal development, synaptic maturation, and learning and memory, like PLC-IP3R, PI3K-Akt, and MAPK-CREB (Segal and Greenberg, 1996)

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In brief, the WADA Prohibited List Committee noted there is not rigorous evidence that clearly demonstrated performance enhancement

As with any medication, potential side effects, drug interactions, and contraindications must be reviewed