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Potential side effects of L-carnitine supplementation include: Nausea Vomiting Stomach cramps Diarrhea A fishy body odor Muscle weakness in people with chronic kidney disease An increased risk of seizures in people with a seizure disorder Additionally, Tallent says L-carnitine supplementation may also elevate trimethylamine-N-oxide (TMAO) blood levelsa risk factor for atherosclerosis, the medical term for clogged arteries

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Therefore, it can be indirectly indicated that LC supplementation is beneficial for the alleviation of PNSD symptoms in diabetic patients [76]

Beyond the approval of different botulinum toxin preparations for the treatment of sialorrhea, efforts to address the plethora of non-motor symptoms of the disease have not translated to novel PD-specific approvals over the last few years