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Funding This paper was supported by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre

The bioconjugation of the aptamers onto the nanoparticulate systems can be attained via non-covalent (affinities interaction e.g., streptavidin-biotin or metal ion co-ordination) and covalent (1-ethyl-3-carbodiimide or succinimdyl ester-amine chemistry and N -hydroxysuccinimide activation chemistry which cross link the carboxylic acid group on the surface of the nanoparticles and the amino group of the ligands) interactions

Investors believe it's a $1-billion-to-$3-billion-a-year market, but hard figures are elusive, because most peptides are sold on the quasi-legal gray market

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