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First identified as a major component of thymus gland secretions, TB500 regulates actin polymerization, which helps cells move efficiently to injury sites

These stiff gels activate the mechanosensitive ion channel (MIC) TRPV4, which upregulates the activity of the phatidylinositol 3-kinase(PI3k)/Akt pathway, triggering the expression of heat shock protein-(HSP-) 70, which protects against stress-induced cell death [119]

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Developmental BPA exposure can also target sensory systems, leading to malformed otoliths 67 , inhibited regeneration of lateral line neuromasts 68 , reduced responses to green and red light 25 , and reduced habituation and prepulse inhibition in response to an auditory startle stimulus 69