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1) were assessed by pathway enrichment in MetaboAnalyst 6.0 using the Small Molecule Pathway Database (SMPDB) with 99 metabolite sets from normal human metabolic pathways and was enriched for Methionine Metabolism, Phenylacetate Metabolism, Pantothenate and CoA Biosynthesis, Pyrimidine Metabolism, Glycine and Serine Metabolism, Arginine and Proline Metabolism, Riboflavin Metabolism and Betaine Metabolism (Fig

In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors

Administration of Sativex an approved oromucosal spray (Health Canada and various European health agencies) containing THC (5 mg/kg) and CBD (5 mg/kg) for the treatment of symptoms associated with MSreduced astrocyte reactivity and decreased the expression of pro-inflammatory cytokines released by microglia in a mouse model of MS (Feli et al., 2015)

Nature 539, 197206