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l-2HG Production at Bioreactor Scale In order to test if l-2HG production by strain HPGluA2 is stable at larger volumes, 2 L scale bioreactor fermentations were performed

### Regulatory Status and Availability **AOD-9604:** - Never received FDA approval for any indication - Classified by the FDA as a **Category 2 bulk drug substance** not eligible for compounding under Section 503B - Removed from many international peptide supplier platforms (including Alibaba and related marketplaces) - Legal status varies by country

Among 80 patients undergoing chemotherapy, 40 received a daily supplement of 500 mg of curcumin

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