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Notably, several drugs targeting the ERK pathway have been shown to have desirable therapeutic effects in alleviating ferroptosis

In 1968, in recognition of this important achievement, Nirenberg was named a co-winner of the Nobel Prize in Physiology or Medicine

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FIGURE 4 8.1 Iron metabolism dysregulation Iron is unevenly distributed in the cerebral cortex: the metal burden in motor-related nucleiincluding the basal ganglia, amygdala, substantia nigra, hippocampus, and red nucleusis significantly higher than in other neural regions (Bartzokis et al., 2007)