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This was associated with increased anxiety-like behaviors as well as decreased KDM6B occupancy and increased H3K27me3 occupancy at the Arc synaptic activity response element (SARE) site and promoter

The dose of PYY-based compounds was escalated at day 4 from 100 nmol kg 1 to 500 nmol kg 1

This enhanced synchronization probably results from phase-locked action-potential firing within the motor cortexbasal ganglia circuit 65

Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested