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The rule is seldom enforced, Thiersch said

In stressed cells NRF2 is released and taken from the cytoplasm into the nucleus by karyopherins (Theodore et al., 2008

While more human trials are needed to further explore this topic, one study showed depleted levels of glutathione in the hippocampus of generally healthy elderly persons, resulting in mild cognitive impairment, a precursor to more advanced impairment down the road