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However, nearly 30% of patients eventually develop drug-refractory epilepsy, which significantly affects the quality of life and psychological health of patients, posing a major societal burden [1]

Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38

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However, for drugs such as lithium, milnacipran, pregabalin, and gabapentin that are not metabolized or little metabolized, and that are eliminated by renal excretion, 10 half-life increases in proportion to the severity of the renal disease