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Safety screening should consider thyroid cancer history, multiple endocrine neoplasia type 2, pancreatitis, gallbladder disease, kidney disease, severe stomach-emptying problems, diabetic eye disease, eating disorders, pregnancy plans, and breastfeeding

R., Schelter J., et al

While you can obtain B12 through your diet, oral supplements are an alternative, and B12 injections are an increasingly popular choice for their efficiency and effectiveness

Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority