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For example, NFAT5 activates mTOR-IRF3/7 to exacerbate kidney injury in patients and mouse models of lupus nephritis [51], and its interaction with NF-B enhances glycolysis and inflammatory responses in macrophages during sepsis [52]

Second, dispersers may suffer reduced survival or reproductive success because of unfamiliarity with the new environment and the inability to acquire sufficient resources, resulting in decreased adaptive ability to the new habitat