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Using genetically engineered V79 Chinese hamster fibroblasts that expressed human CYP1A2, N(O)-acetyltransferase (hNAT2*4) and sulphotransferase (hSULT1A1*1), Platt et al

ALOX5 is involved in ferroptosis triggered by erastin or RSL3 (66), which can be suppressed by its binding protein microsomal glutathione S-transferase I (MGSTl) (67)

Pauwels E.K., Erba P.A

This suggested that the primary mode of cell death in mouse hepatocytes is necrosis but if this signaling process is inhibited downstream at the mitochondrial level, secondary apoptosis can develop [37]