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Clinical study characteristics All included studies were categorized based on key characteristics, including study duration, start year, geographical location and the number of clinical centers involved

Shortly after the original identification, the copper-binding role was established, and the conceptual framing shifted toward GHK as a copper-delivery peptide whose proliferation-supporting activity in the original assays reflected the role of copper in cellular biology rather than a direct growth-factor signaling activity in the classical sense

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