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This effect is a consequence of the increase in 2,3-bisphosphoglycerate concentration in red blood cells

For example, PRDM16 divergent transcript (PRDM16-DT) is downregulated in AD, whereas nuclear enriched abundant transcript 1 (NEAT1) is upregulated and associated with reactive astrocyte states and cognitive impairment 33

It achieves this through autocrine, paracrine and endocrine interactions between stromal and breast cancer cells within many microenvironments: the primary tumor site, the circulation and/or host tissue and migrating tumor cells at metastatic sites (Figure 1)

This can assist in reducing some of these ailments