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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

Regulatory and Legal Challenges The evolving regulatory landscape creates ongoing challenges for healthcare providers and patients

Hallak H, Seiler AEM, Green JS et al (2000) Association of heterotrimeric Gi with the insulin-like growth factor-I receptor: release of G subunits upon receptor activation

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