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Specifically, cysteine deprivation disrupted oxidative phosphorylation, the main process for producing adenosine triphosphate (ATP), the molecule that serves as cells energy currency

In addition to AGEs and AGE adducts, HMGB1 and A can bind RAGEs to activate the NF-B, ERK1/2, p38, JNK, PI3K, Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, leading to neuronal cell death and neurodegeneration 112

We proposed that HSCs could sense aging-associated intrinsic or extrinsic cellular insults and initiate epigenetic inflammatory training, resulting in heightened inflammatory response to aging-associated damage-associated molecular patterns in distant tissues

This aspect is discussed in detail in Sect